Measure content performance. Develop and improve products. List of Partners vendors. If you've had your cholesterol checked before, you have probably noticed a lot of different types of cholesterol listed on your lab result. All of these types of cholesterol may be made up of similar parts, but their functions in the body are different. Having elevated or lowered levels of some of these forms of cholesterol may increase your risk of developing heart disease. Cholesterol and triglycerides are fatty molecules.
Because of their fat-like properties, they are not able to easily circulate in the bloodstream. In order for cholesterol and triglycerides to travel in the blood, they are often carried by proteins that make the cholesterol and triglycerides more soluble in blood.
This lipid and protein complex is referred to as a lipoprotein. When triglycerides and cholesterol are removed from this lipoprotein complex, and you have the protein alone, the protein component is referred to as an apolipoprotein. Different types of apolipoproteins are associated with different lipoproteins. There are five different types of lipoproteins in the blood, and they are commonly classified according to their density.
These lipoproteins consist of mainly triglycerides, some cholesterol molecules, and less protein. In this case, VLDL is less dense than most lipoproteins because of its high lipid composition.
VLDL is made in the liver and is responsible for delivering triglycerides to cells in the body, which is needed for cellular processes. As triglycerides get delivered to cells, VLDL is made up less of fat and more of protein, leaving cholesterol on the molecule. LDL consists of more cholesterol than triglycerides and protein. Because it contains less lipid and more protein in comparison to VLDL, its density is greater.
LDL is responsible for carrying cholesterol to cells that need it. Elevated LDL levels are associated with an increased risk of cardiovascular disease. HDL is made in the liver and in the intestines. It is responsible for carrying cholesterol from cells back to the liver. They are the densest of the lipoproteins, as they contain a high amount of protein and a smaller amount of lipids.
HDL and LDL are very commonly measured lipoproteins in the clinical laboratory due to their important and opposite biological functions. Patients and the public often refer to HDL cholesterol as "good cholesterol," as it removes cholesterol from blood vessel walls and returns it to the liver for other uses.
In fact, high serum levels of HDL are associated with a decrease in the risk of atherosclerosis. Conversely, LDL cholesterol is often referred to as "bad cholesterol," as it delivers cholesterols to cells where it is stored and accumulates. From the rates of infusion and the steady-state plasma levels attained, the whole animal clearance rates for cholesterol carried in low density and high density lipoproteins and in chylomicrons were calculated to be 0.
Hepatic cholesterol ester content increased by 0. The rate of hepatic cholesterol synthesis was inhibited by a factor of 0.
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